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GPR132 is described in neutrophils (170) and macrophages and appears to be responsible for migration to recruit macrophages in the pro-inflammatory microenvironment surrounding the focus of inflammation (171)

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Another study indicates the reduction in risk (found to be closer to 30% for those drinking 5 cups a day) may be due to something else in coffee other than caffeine, because other caffeinated drinks did not give the same result.[ref][ref] For those with the BRCA1 mutation , one study found that coffee consumption before age 35 for those with the C-allele reduced their relative risk of breast cancer by 64%.[ref] Another meta-analysis found that high coffee consumption may lead to a decreased risk of pancreatic cancer .[ref] Coffee and caffeine have been shown to reduce inflammation, including neuroinflammation, in a manner that is dependent on ADORA2A.[ref][ref] Coffee: Genotype Report Access this content: An active subscription is required to access this content